It is a colorless, odorless, and sweet-tasting solution. The toxic dose of undiluted antifreeze in cats is 1.4ml per kg body weight This means a standard 10lb (4.5kg) cat only needs to drink a little over 6ml of antifreeze to develop a fatal poisoning. Activated charcoal is not likely to reduce absorption of EG from the GI tract. Treatment is aimed at decreasing absorption of ingested EG, increasing excretion of unmetabolized EG, preventing metabolism of EG, and correcting the metabolic acidosis that occurs with EG metabolism. Ethylene glycol, the toxic component of antifreeze, causes severe kidney damage. What are the signs of antifreeze poisoning in cats? https://www.petmd.com/cat/conditions/urinary/c_ct_antifreeze_poisoning fluid diuresis, dialysis, IV ethanol or 4-Methylpyrazole (4-MP, fomepizole) signs of zinc toxicity. Calcium oxalate crystals appear birefringent when viewed with polarized light. Cutaneous absorption from topical products that contain EG has been reported to cause toxicity in cats. The problem with ethylene glycol is that it can be very toxic when ingested, often causing rapid and frequently fatal injury to the kidneys. Cattle may become depressed, tachypneic, and ataxic, and develop paraparesis or recumbency. Pathophysiology  Like the other toxic alcohols mentioned above, ethylene glycol is a parent compound that exerts most of its toxicity by conversion to metabolites. Ethylene glycol polymers with large carbon chains may be reproductive toxins, but ethylene glycol itself exhibits no developmental toxicity or detrimental effects to reproductive health in humans. Ethylene glycol poisoning is most common in temperate and cold climates because antifreeze is used both to decrease the freezing point and to increase the boiling point of radiator fluid. The onset of clinical signs is almost immediate and resembles alcohol (ethanol) intoxication. Additional doses of bicarbonate based on the above formula are frequently necessary. About. Fermented products such as bread dough and rotten apples, food that a cat can easily find while digging through the garbage, is one source of toxicity. Pet Poison Helpline is not directly affiliated with LifeLearn. This testing method is very accurate, but not always available in the middle of the night. A teaspoon of ethylene glycol could kill your cat. Ethylene glycol has been shown to be toxic to humans and is also toxic to domestic pets such as cats and dogs. Other sources of EG include some heat-exchange fluids used in solar collectors and ice-rink freezing equipment and some brake and transmission fluids. Antifreeze is a common product used in car radiators to lower the freezing point of water in cooler climates. Causes. Signs include lethargy, anorexia, dehydration, vomiting, diarrhea, oral ulcers, salivation, tachypnea, and possibly seizures or coma. Ethylene glycol is metabolized in the animal’s body to several extremely toxic chemicals that are responsible for its potentially lethal effects. What are the signs of ethylene glycol poisoning? It is often claimed that cats are attracted to the sweet taste of antifreeze, but as cats cannot taste sweet. Within 30 minutes of ingestion, they may resemble a person who has had too much to alcohol drink. Phase 1 signs include ataxia and a … Ethylene glycol has a very narrow margin of safety – which means only a tiny amount can result in severe poisoning. The prognosis varies inversely with the amount of time that elapses between ingestion and initiation of treatment. In colder climates, the incidence of EG intoxications is seasonal, with most cases occurring in the fall, winter, and early spring, when antifreeze is added to radiator fluid or when cooling systems are flushed. This damage can be identified in a serum biochemistry profile by increases in the levels of creatinine and BUN (blood urea nitrogen) that are normally removed from the blood by the kidneys. Stage 1 (within 30 minutes of ingestion): The signs include lethargy, vomiting, incoordination, excessive urination, excessive thirst, hypothermia (low body temperature), seizures, and coma. Monohydrate calcium oxalate crystals (clear, 6-sided prisms) are more common than dihydrate calcium oxalate crystals (maltese cross or envelope-shaped). Ethylene glycol toxicity Ethylene glycol poisoning. The pH derangement seen with ethylene glycol toxicity is _____. Acidosis (acidic blood) can also be detected through the biochemistry profile. 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